Overview of Picked Chemical Compounds and Intermediates
Overview of Picked Chemical Compounds and Intermediates
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1. Pharmaceutical Intermediates
Bortezomib Acid Impurity: This can be an impurity linked to bortezomib, a proteasome inhibitor Utilized in the cure of a number of myeloma. Its synthesis or examine is essential for making sure the purity and basic safety from the drug.
Abiraterone Acetate Intermediate (CAS NO. 122111-01-seven): A precursor inside the synthesis of abiraterone acetate, a drug Employed in the therapy of prostate cancer by inhibiting androgen manufacturing.
Imatinib Intermediate (CAS NO. 152460-ten-1): A crucial compound within the synthesis of imatinib, a drug that targets unique different types of cancer, such as Serious myelogenous leukemia (CML).
Docetaxel Intermediate: A compound Employed in the synthesis of docetaxel, a chemotherapy medication that treats many cancers for instance breast, lung, and prostate cancer.
two. Chemical Impurities and Byproducts
GeMcitabine Intermediates (T6, T9, 8): They are intermediates in the synthesis of gemcitabine, an anti-cancer drug. Their study is important for optimizing the generation method and ensuring superior purity.
Lapatinib Intermediate (CAS NO. 231278-84-5): Lapatinib is applied to treat breast cancer, and these intermediates are involved with its output.
Fulvestrant Intermediates: Fulvestrant is definitely an estrogen receptor antagonist Employed in the therapy of breast most cancers. Several intermediates help in the synthesis of the drug.
Paclitaxel Aspect Chain Acid (CAS NO. 949023-16-9): This intermediate is Employed in the synthesis of paclitaxel, a chemotherapy drug efficient in dealing with cancers including ovarian, breast, and lung most cancers.
3. Other Notable Compounds
Irinotecan Hydrochloride Trihydrate (CAS NO. 136572-09-3): A chemotherapy drug Utilized in the cure of colorectal most cancers and little cell lung cancer.
3-Amino-one-hydroxyadamantane (CAS 702-eighty two-nine): This compound is associated with the synthesis of adamantane derivatives, that have various applications, which includes antiviral Houses.
Vildagliptin Intermediates: Utilized in the manufacture of vildagliptin, an oral drug for form two diabetic issues that inhibits the enzyme DPP-4 to regulate blood sugar ranges.
4. Miscellaneous Compounds
D-Gluconic Acid δ-Lactone (CAS NO. (7a 61259-48-1): This compound is associated with the synthesis of varied gluconic acid 4-(dimethylamino)- derivatives, which are used in food, pharmaceutical, and industrial programs.
Canagliflozin Intermediate 2: A precursor from the synthesis of canagliflozin, a medication made use of to manage style 2 diabetes by inhibiting sodium-glucose co-transporter two (SGLT2).